Bone Metabolism Biochemical Profiles in Aged Patients with Type 2 Diabetes Mellitus

Obejective:To investigate the changes of bone mineral density (BMD) and various metabolism biochemical profiles and to elucidate the relevant risk factors for osteoporosis in senile patients with type 2 diabetes mellitus (T2DM). Methods:Bone density, some biochemical indexes and bone metabolic parameters were detected in 110 male patients with T2DM and 87 normal controls. Results: The incidence rate of BMD reduction, urine deoxypyridinoline (Dpd) and fasting plasma glucose (FPG) in diabetic patients was significantly higher than those in control group (P0.01), while the serum level of bone gla-protein (BGP) and insulin (INS) in diabetic group were both significantly lower than that of control group (P0.01). Conclusion:Osteoporosis can easily occur in senile patient with T2DM. BMD, BGP and Dpd are important indexes to diagnose diabetic osteoporosis (DOP), while fine control of the levels of blood glucose and blood lipids aiming to protect pancreatic-cell may reduce the occurrence of osteoporosis.