Hyperalpha- and hypobeta-lipoproteinemia in octogenarian kindreds☆
1977
Abstract To assess factors related to distinctive longevity, lipoprotein and kindred studies were carried out in 22 octogenarian kindreds self-referred by virtue of either two siblings or a parent and child living to age 80 or over. There was evidence for familial hyperalpha-lipoproteinemia in 7 kindreds, for familial hypobeta-lipoproteinemia in 3 kindreds, and for primary hyperalpha-lipoproteinemia and hypobeta-lipoproteinemia in an additional 2 and 2 kindreds respectively. First degreee relatives of probands with primary or familial hyperalpha- or hypobeta-lipoproteinemia had sharply reduced morbidity and mortality from myocardial infarction when compared to population controls, P P P
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