Clinical study of renal vessel function damage of patients with chronic obstructive pulmonary disease

Objective To investigate the impact of chronic obstructive pulmonary disease (COPD) on renal vessel function. Methods Eighty-two patients with stable phase COPD and 46 healthy people were recruited in the study. According to arterial blood gas analysis results, the subjects were divided into three groups, group A consisted of 34 COPD patients complicated with respiratory failure; group B consisted of 48 COPD cases without comorbidity, and group C consisted of 46 cases of healthy people. The clinical and laboratory indicators were compared among the different groups. Results ①Gender, age, BMI, SBP, DBP, Cr and BUN level in each group showed no significant difference (P>0.05). FEV1% of pulmonary function test, CAT grade, PaO2, hsCRP level in different groups showed significant difference (P 0.05). The plasma Cys-C levels of patients with COPD(group A and group B) were higher than those of group C(P 0.05). ③Linear correlation analysis showed that U-mALB level was correlated with FEV1%, Cys-C, CAT grade, PaO2, hsCRP(P<0.05), and Cys-C level was correlated with FEV1%, U-mALB, CAT grade, PaO2, hsCRP(P<0.05). Conclusions The increased U-mAlB and Plasma Cys-C levels are predictors of early renal injury in patients with COPD. Key words: Chronic obstructive pulmonary disease; Urine-micro albumin; Cystain C