Синтез и биологическая активность новых производных 6-бензилизоцитозина: ненуклеозидных ингибиторов обратной транскриптазы вич-1

New 6-benzylisocytosine derivatives have been synthesized by aminolysis of 6-benzyl-2-(methylsulfanyl)pyrimidin-4(3H)-one derivatives with aliphatic aromatic and cage-structured amines. Some of the synthesized compounds appeared to be effective HIV-1 reverse transcriptase inhibitors. Among these, 6-(2,6-difluorobenzyl)-5-methyl-2-[(2-phenylethyl)amino]pyrimidin-4(3H)-one showed the most pronounced inhibitory properties, being nine times more effective than the reference anti-HI»V drug nevirapine.