GASTROPR OTECTIVE ACTIVITY OF PONGAMIA PINNATA STEM BARK IN WISTA R ALBINO RATS

The present study was carried out with the stem bark of Pongamia pinnata Linn, belonging to the family Fabaceae. It is one of the fast growing, glabrous, deciduous tree and has recently gained importance as a commercial source of al kaloids like kaempferol, karanjin. Methanolic extract of Pongamia pinnata was subjected to phytochemical screening. Acute gastric ulceration was produced by oral administration of various noxious chemicals including E thanol, Indomethacin, Pylorus ligation and Cold restraint stress. In pharmacological screening, the effect of methanolic extract of stem bark of Pongamia pinnata Linn was evaluated in Wistar Albino Rats of either sex(150 200g) for Antiulcer activity at a dose of 200mg/kg and 400mg/kg(p.o) and the effect was compared with Omeprazole(10mg/kg p.o) as standard drug. The extract decreased the ulcer index thereby increasing the percentage ulcer protection. Thus from the study and literature, it can be concluded that Pongamia pinnata Linn have potent antiulcer activity.