Intratumoral Spatial Heterogeneity at Perfusion MR Imaging Predicts Recurrence-free Survival in Locally Advanced Breast Cancer Treated with Neoadjuvant Chemotherapy

We discovered and validated three intratumoral subregions with distinct MR perfusion imaging parameters. In addition to clinical-pathologic and genomic factors, intratumoral spatial heterogeneity characterized by MR imaging was an independent predictor of recurrence-free survival in two breast cancer cohorts.