Is anti-müllerian hormone associated with fecundability? Findings from the EAGeR trial

Objective: The objective of the study was to evaluate whether anti-Mullerian hormone (AMH) is associated with fecundability among women with proven fecundity and a history of pregnancy loss. Design: This was a prospective cohort study within a multicenter, block-randomized, double-blind, placebo-controlled clinical trial (clinicaltrials.gov, number NCT00467363). Setting: The study was conducted at four US medical centers (2006–2012). Participants: Participating women were aged 18–40 years, with a history of one to two pregnancy losses who were actively attempting pregnancy. Main Outcome Measures: Time to human chorionic gonadotropin detected and clinical pregnancy were assessed using Cox proportional hazard regression models to estimate fecundability odds ratios (fecundability odds ratios with 95% confidence interval [CI]) adjusted for age, race, body mass index, income, low-dose aspirin treatment, parity, number of previous losses, and time since most recent loss. Analyses examined by preconception AMH l...