Long range 1H19F coupling through multiple bond in thienopyridines, isoquinolines and 2-aza-carbazoles derivatives

Abstract Long range 5 J and 6 J ( 1 H 19 F) spin-spin coupling constants for a set of nine biarylic fluorinated derivatives were determined by 1 H NMR experiments. The quantitation of these long-range 5 J and 6 J ( 1 H 19 F) coupling can be found through the measure of the residual coupling-signals obtained after the selective decoupling process. The information obtained for the NMR spectra was confirmed through computational studies.