JAK/Stat5-mediated subtype-specific lymphocyte antigen 6 complex, locus G6D (LY6G6D) expression drives mismatch repair proficient colorectal cancer

Guido Giordano,Pietro Parcesepe,Mario D'Andrea,Luigi Michele Coppola,Tania Di Raimo,Andrea Remo,Erminia Manfrin,Claudia Fiorini,Aldo Scarpa,Carla Azzurra Amoreo,Fabiana Conciatori,Michele Milella,Francesca P. Caruso,Luigi Cerulo,Almudena Porras,Massimo Pancione

JAK/Stat5-mediated subtype-specific lymphocyte antigen 6 complex, locus G6D (LY6G6D) expression drives mismatch repair proficient colorectal cancer

2019

Guido Giordano
Pietro Parcesepe
Mario D'Andrea
Luigi Michele Coppola
Tania Di Raimo
Andrea Remo
Erminia Manfrin
Claudia Fiorini
Aldo Scarpa
Carla Azzurra Amoreo
Fabiana Conciatori
Michele Milella
Francesca P. Caruso
Luigi Cerulo
Almudena Porras
Massimo Pancione

Background Human microsatellite-stable (MSS) colorectal cancers (CRCs) are immunologically “cold” tumour subtypes characterized by reduced immune cytotoxicity. The molecular linkages between immune-resistance and human MSS CRC is not clear.

Keywords:

Cancer research
STAT5
Biology
Locus (genetics)
DNA mismatch repair
Lymphocyte
Immune system
Antigen
Cytotoxicity
Colorectal cancer
Molecular biology
Cancer cell
Antibody
MEK inhibitor
Immune checkpoint
Trametinib
B7-H1 Antigen

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