Current Status of Induction of Specific Unresponsiveness to Organ Allografts

Few, if any, purposeful attempts have been made to induce specific unresponsiveness to organ allografts in man. Nevertheless, there is an enormous experimental literature to show that attempts to induce unresponsiveness of some type in man are a reasonable undertaking. It is the purpose of this chapter to identify the principles and problems in the induction of unresponsiveness to allografts. No attempt will be made to review the enormous literature of this subject. Rather, experimental models developed and studied by our own group will be described to illustrate how clinical attempts for unresponsiveness induction could be undertaken.