General Endocrine Therapy

Testis must not be seen as a static organ, but rather as a dynamic organ that might respond by increasing its function, both steroidogenesis and spermatogenesis, in response to proper stimuli. Furthermore, these two testicular functions are interchangeable and intrinsically related to each other. The hypothalamic–pituitary–gonadal (HPG) axis acts in the Leydig cell through the secretion of luteinizing hormone (LH) and in the Sertoli cell through the action of the follicle-stimulating hormone (FSH), and knowing its physiology allow the proper management of male infertility.