Studies on biliary tract carcinoma in the case with pancreaticobiliary maljunction.

Background/Aims: The purpose of this study was to clarify the clinicopathological features of pancreaticobiliary maljunction and to determine the appropriate surgical approach fur biliary tract with pancreaticobiliary maljunction. Methodology: The data of 77 patients with pancreaticebiliary maljonction including 13, who had been treated for biliary tract cancer, were reviewed retrospectively. We assessed the clinical features, biological characteristics of the cancer, methods of surgical treatment, postoperative outcome and cell proliferating activity of the bihary epithelium, evaluated by the PCNALI (proliferating cell nuclear antigen-label ing index). Results: The incidence of cancer development in the case with panercaticabiliary maljunction was 13.4% in the bile duct dilatation group (n=67) and 48.0% in the non-dilatation group (n=10). Dissection of lymphadenectomy was performed in 10 (78.9%) of 13 patients, and curative resection was feasible in 9 of the 10 patients. Two (20.0%) of the 10 patients had lymph node involvement noted at surgery and died of recurrence. In the other eight patients without lymph node involvement at surgery, six patients anderwent curative resection and are alive at 7 months to 11 years and 6 months after surgery. PCNALI of the biliary spithelium of the patients with pancreaticabiliary maljunction was significantly higher than that of the control group. Conclusions: For patients with pancreaticabiliary maljunction, it should be stressed that the extrahepatic bile duct be prophylactically removed, even when there are no neoplasmatic changes because of high prevalence of cancer development, presumably predicted by the increase of cell prolifecative activity in the biliary epithelium. For patients with biliary can cer, early detection at the stage with no lymph node involvement in essential to secure for long-term survival.