The Immunocapacity of the AKR Mouse

Summary Mice of the high leukemia strain, AKR, possess immunocompetent lymphocytes and are capable of participating in both immediate and delayed types of hypersensitivity reactions. These responses can be demonstrated undiminished throughout the life-span of the animal, even extending into the leukemic stage. A 35% mortality from anaphylaxis occurred in 2-month-old AKR mice, and an 87% mortality occurred in those AKR mice older than 7 months. Spleen cells from AKR mice aged 1 to 11 months produced a graft- versus -host reaction in newborn CFW mice.