Synthesis of Oligonucleotides via Phosphoramidite Approach Utilizing 2- Diphenylmethylsilylethyl (DPSE) as a Phosphorus Protecting Group.

Abstract 2-Diphenylmethylsilylethyl (DPSE) is a new protecting group for internucleotidic bonds in the synthesis of oligodeoxyribo nucleotides by the phosphoramidite approach. This group is stable to acidic conditions and can be removed under mild β-fragmentation conditions using aqueous ammonium hydroxide.