Effects of a Novel Mouthwash on Dental Remineralization
2017
Objective: The goal of this study was to evaluate the in vivo effects of a novel mouthwash on enamel
remineralization.
Materials and Methods: Ten healthy volunteers wore removable intra-oral appliances for three study arms with
duration of 5 days each. In 1 study arm, subjects used Oral Essentials Sensitivity FormulaR mouthwash; in another
arm they used SensodyneR mouthwash, and in the third arm they used no mouthwash at all. Sequence of
mouthwash use was randomized, and study participants and researchers were blinded throughout the study.
Subjects used Crest Total CareR toothpaste throughout the study. During a one week washout period before study
begin and between each study arm, subjects also used Crest Total CareR toothpaste. A total of 300 enamel samples
were included in this study, 150 of served as baseline controls, and 150 as test samples subjected to
demineralization prior to intra-oral wear. At the end of each study arm, enamel chips were removed from the
appliance and underwent standard Microhardness (Knoop) measurements, as did the control samples. Enamel
microhardness in the test vs the 2 control groups was compared using the Kruskal-Wallis one-way analysis of
variance with post-hoc Tukey’s test to test for differences in remineralization between the 3 treatments.
Results: Both mouthwashes demonstrated similar levels of recovery from demineralization as the “no
mouthwash” arm of the study, with no significant differences for all groupings and comparisons (p>0.05).
Conclusion: A novel mouthwash for sensitive teeth supports enamel recovery from demineralization.
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