The CYBA Gene 49A>G Polymorphism (rs7195830) Is Associated with Hypertension in Patients with Coronary Artery Disease

Purpose. Single nucleotide polymorphisms of the CYBA gene may modify the risk of coronary artery disease (CAD). The aim of the present study was to investigate whether the 49A>G (rs7195830) polymorphism is associated with CAD. Materials and Methods. CYBA gene 49A>G polymorphism was determined in 481 subjects: 242 patients with premature CAD and 239 age and sex matched controls using the fluorescently labeled allele-specific oligonucleotides method. Results. The frequency of the 49G allele carrier state was significantly higher in patients than in controls (84.8% versus 76.6%, resp., ), as well as the frequency of the 49G allele (62.2% versus 54.0%, ). Both factors were associated with CAD in the analyzed population (OR = 1.70, 95% CI: 1.04–2.76 for GG