The Structure of PEG-Modified Poly(Ethylene Imines) Influences Biodistribution and Pharmacokinetics of Their Complexes with NF-κB Decoy in Mice

Klaus Kunath,Anke von Harpe,Holger Petersen,Dagmar Fischer,Karlheinz Voigt,Thomas Kissel,Ulrich Bickel

The Structure of PEG-Modified Poly(Ethylene Imines) Influences Biodistribution and Pharmacokinetics of Their Complexes with NF-κB Decoy in Mice

2002

Klaus Kunath
Anke von Harpe
Holger Petersen
Dagmar Fischer
Karlheinz Voigt
Thomas Kissel
Ulrich Bickel

Purpose. To study the relationship between structure of poly(ethylene imine-co-ethylene glycol), PEI-PEG, copolymers and physicochemical properties as well as in vivo behavior of their complexes with NF-κB decoy.

Keywords:

Ethylene glycol
Decoy
Biochemistry
Ethylene
Drug carrier
Chemistry
NF-κB
Pharmacokinetics
Biodistribution
Gene delivery
Polyethylenimine
PEG ratio
In vivo
Stereochemistry

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