Ürtikerli Hastalarda Tiroid Otoimmunitesinin Araştırılması

Objective: An autoimmune etiology has been suggested in up to one-third of cases of chronic idiopathic urticaria (CIU). It is known that thyroid autoimmunity may be associated with urticaria. The objective of our present study was to verify the prevalence of thyroid antibodies in the patients with urticaria. Material and Methods: Seventy nine patients aged 14–70 years, who met criteria for urticaria, and 40 agedmatched healthy controls (10 males and 30 females) were participated in this study. Serum thyroid-stimulating hormone (TSH), free T3, free T4, anti-peroxidase (TPO), and anti-thyroglobulin (anti-Tg) antibody levels were measured. Results: The total ATA positive rate was 26.7% in the CIU group. The prevalence of anti-TG, and anti-TPO were 10.7 %, 17.9 % respectively. The prevalance of anti TPO was significantly higher in patients with CIU than controls (p=0,023). The total ATA positive rate was %10 in the acute urticaria. Conclusion: We determined that the prevalance of thyroid antibodies was significantly higher in our CIU patients. It is important to evaluate the relationship between thyroid auto-immunity and thyroid function in CIU patients. Understanding this relationship will be potentially useful in evaluating the treatment benefits of either thyroidhormones or anti-thyroid drugs in resistant cases of CIU