NEW 6H- INDOLO(2,3-B)QUINOLINE O-AMINOGLYCOSIDES OVERCOMING ANTICANCER MULTIDRUG RESISTANCE

Novel derivatives of 6H- indolo(2,3-b)quinoline substituted at C-2, C-9 or N-6 positions with O- L-daunosamine or L-acosamine connected with the chromophore via an alkoxy or alkyl linker were synthesized. The obtained compounds were evaluated in vitro for their cytotoxic activity against several cell lines of different origin and tested for their ability to influence the cell cycle using the flow cytometric analysis. All the compounds tested show cytotoxic activity against A549, MCF-7 and Hs294T cells and overcome multidrug resistance in colorectal adenocarcinoma LoVo/DX, uterine sarcoma MES-SA/DX5 as well as promyelocytic leukemia HL-60/MX2. The compounds also induce the G2M or G0/G1 phase cell cycle arrest in the Jurkat T-cell leukemia cells.