Hydrogen Atom Transfer-Initiated Radical Cyclization of Alkene-Tethered Ketones

An unprecedented hydrogen atom transfer-based C-C coupling reaction between alkenes and ketones using Fe(acac)3 and PhSiH3 in EtOH is described. This mild protocol features high site-selectivity and allows for the construction of sterically congested structures containing tertiary alcohols and quaternary centers. The overall process introduces a novel strategic bond disconnection for ring-closing reactions.