MDM2 oncogene, E3 ubiquitin protein ligase T309G polymorphism and risk of oesophageal or gastric cancer: Meta-analysis of 15 studies

ObjectiveTo investigate the association between potentially functional MDM2 oncogene, E3 ubiquitin protein ligase (MDM2) T309G polymorphism and susceptibility to oesophageal or gastric cancer.MethodsTwo investigators independently searched the PubMed and Chinese National Knowledge Infrastructure databases for studies published before September 2013.ResultsPooled results showed that the variant homozygous 309GG genotype (versus TT) was significantly associated with increased risk of both oesophageal (odds ratio [OR] 0.77; 95% confidence interval [CI] 0.65, 0.90) and gastric cancer (OR 0.52; 95% CI 0.38, 0.72). Subgroup analysis revealed a 309GG-associated increased risk for both cancer types in Asian populations, particularly among Chinese and Japanese ethnicity. When stratified for Helicobacter pylori infection and histological type of gastric cancer, the 309GG-related risk was higher in H. pylori-positive patients (T versus G: OR 0.37; 95% CI 0.22, 0.63) and the association was stronger with intestinal (...