Sialic Acid-deficient |[alpha]|1-Acid Glycoprotein produced in Certain Pathological States

THE seromucoid fraction, one of the ‘acute phase react ants’, has been shown by many investigators to be increased significantly in the blood in a large number of unrelated disease states. This protein fraction1 is known to contain as major component α1-acid glyco-protein2 or orosomucoid3 and several minor components including haptoglobin, 3S α1-glycoprotein and Zn- and Ba-α2-glycoproteins4,5. The question has now been investigated whether α1-acid glycoprotein derived from pathological plasma is identical to or different from that prepared from normal blood.