Nitrite reduces ischemia/reperfusion-induced muscle damage and improves survival rates in rat crush injury model.

BACKGROUNDNitrite is an intrinsic signaling molecule with potential therapeutic implications in mammalian ischemia/reperfusion (I/R) injury of the heart, liver, and kidney. Although limb muscle compression and subsequent reperfusion are the causative factors in developing crush syndrome (CS), there