Association of single nucleotide polymorphism of interleukin 6 receptor gene and metabolic syndrome
2012
The association of interleukin 6 receptor ( IL-6R ) gene - 183 A/G ( rs4845617 ) and Asp358 Ala (rs8192284 A/C) polymorphisms with metabolic syndrome was investigated in Chinese Han population.The result showed that the frequencies of AA genotype and A allele were higher in patients with metabolic syndrome ( MS ) than those in healthy subjects ( P<0.05 or P<0.01 ).The risk of MS in patients with A allele was 1.643 folds of that with allele C(95% CI 1.163-2.320,P<0.01 ).No differences were found in the genotype and allele frequencies of -183A/G between two groups ( P>0.05 ).The Asp358Ala polymorphism of IL-6R was significantly associated with MS in Chinese Han population.
Key words:
Interleukin 6 receptor; Polymorphism, gene; Metabolic syndrome
Keywords:
- Interleukin 12 receptor, beta 1 subunit
- Interleukin 1 receptor antagonist
- Interleukin-23 receptor
- Interleukin-21 receptor
- Interleukin 1 receptor, type II
- Interleukin-6 receptor
- Molecular biology
- Interleukin 29
- Interleukin 19
- Biology
- Genotype
- Single-nucleotide polymorphism
- Allele frequency
- Internal medicine
- Endocrinology
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