A unification of chirality measures
1995
A general classification of chirality measures is suggested, based on a new unifying scheme. Two classes of measures - congruity and resolution type — are defined All chirality measures so far reported in the literature are found to belong to one of these two classes. At a higher level of unification, a more general construction is suggested that includes congruity and resolution measures as limiting cases. It is shown that congruity measures are nested in clusters of eight, generated by 23 combinations of their possible choice of a reference object (chiral vs. achiral), representation form (optimized vs. factorized) and type of chiral object under consideration (discrete vs. continuous). Each of the eight cases can have an infinite number of variations depending on the choice of averaging scheme. The problem of dimensionality is discussed for congruity measures and is shown to be unresolvable only for the case of chirality measures based on the discrete metric (e.g. overlap measures).
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