Impacto del tratamiento con antibiótico sobre la calidad seminal y los marcadores químicos de glándulas accesorias sexuales masculinas en presencia de Mycoplasma hominis y Ureaplasma urealyticum

Genital infections have been associated with male infertility. Among the microorganisms responsible for these have been highlighted Mycoplasma hominis and Ureaplasma urealyticum whose effects on sperm quality are controversial, and the role of male accessory glands have very little evidence. In the first stage of this study, we evaluated 300 semen samples from men attending infertility consulting. According to microbiological culture and detection of antibodies they were grouped into M. hominis (n = 24) and U. urealyticum (n = 18), and compared with the uninfected group (n = 159). The group M. hominis showed hyposmotic (HOST) (p <0.05) and neutral α-glucosidase (AGN) (p <0.05) decreased. The group U. urealyticum HOST and AGN (p <0.001) were lower; but leukocytes (p <0.001) and pH in semen (p <0.05) increased. In the second stage of the study data of patients who completed three cycles of treatment with doxycycline were compared vs pre-treatment. It was observed increasing in sperm motility and AGN with decreasing of citric acid (p <0.001). At eradicated U. urealyticum sperm motility (p <0.001), HOST (p <0.001), AGN (p <0.001) was increased; with decreasing of leukocytes (p <0.05) and seminal pH (p <0.05). Sperm motility and concentration of citric acid in the two groups after treatment were higher than the group without infection (p <0.05). It is considered important to diagnose and treat seminal infection by M. hominis and U. urealyticum to prevent the negative effect of these bacteria on the sperm and male accessory glands.