Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.

Ryu-suke Nozawa,Koji Nagao,Hiro-Taka Masuda,Osamu Iwasaki,Toru Hirota,Naohito Nozaki,Hiroshi Kimura,Chikashi Obuse

Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.

2010

Ryu-suke Nozawa
Koji Nagao
Hiro-Taka Masuda
Osamu Iwasaki
Toru Hirota
Naohito Nozaki
Hiroshi Kimura
Chikashi Obuse

POGZ is identified as a binding partner for HP1 (Heterochomatin Protein 1) and as a regulator of mitotic progression. It mediates the activation of Aurora B and the dissociation of both HP1 and Aurora B from chromosome arms during mitosis.

Keywords:

Cell biology
Aurora B kinase
Heterochromatin protein 1
Molecular biology
Mitosis
Mitotic chromosome
Chromosome
Regulator
Biology
mitotic progression

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