Abstract 12921: Contemporary Evaluation of Female Gender and Outcomes in Heart Failure With Reduced or Preserved Left Ventricular Systolic Function

Introduction: How gender influences prognosis in heart failure with reduced ejection fraction (HF-REF) compared to preserved ejection fraction (HF-PEF) in contemporary populations is not well described. Hypothesis: In a representative community-based HF population, female gender is independently associated with better outcomes in HF-REF and HF-PEF. Methods: Between 2005-2012, we identified adults with confirmed HF-REF or HF-PEF receiving care in Kaiser Permanente Northern California. Outcomes included death and hospitalizations for HF or any cause. We used extended Cox regression to evaluate the impact of female gender on outcomes after accounting for baseline characteristics, cardiovascular risk factors, medical history and receipt of HF and other cardiovascular therapies based on data from comprehensive electronic health records. Results: Among 24,257 eligible adults with HF-REF or HF-PEF, 11,227 (46%) were women and 13,030 (54%) were men. At entry, women were older and more likely to have HF-PEF, hyper...