THE COMPARISON OF A FOUR-COMPARTMENT AND A FIVE-COMPARTMENT MODEL OF ROSE BENGAL TRANSPORT THROUGH THE HEPATIC SYSTEM

Publisher Summary This chapter presents a comparison of a four-compartment and a five-compartment model of Rose Bengal transport through the hepatic system. It is often very difficult to differentiate the various factors contributing to liver disease. Because the liver performs a multitude of critical tasks involving metabolic functions, vascular functions and secretory functions, an abnormality within the liver could manifest itself as perhaps another physiological dysfunction or vice versa. In search for techniques that will enable a more conclusive differentiation among physiological abnormalities of the hepatic system, a previously studied four-compartment model of Rose Bengal transport has been expanded to a five-compartmental model. The chapter describes this model as a system of coupled difference equations, the solution of which involves nonlinear programming techniques.