Nanofibers Reinforced Injectable Hydrogel with Self-healing, Antibacterial, and Hemostatic Properties for Chronic Wound Healing

Abstract The chronic wounds often hinder wound healing resulting from infection; thus, an ideal wound dressing should be able to maintain a healthy wound microenvironment. Herein, peptide modified nanofibers reinforced hydrogel has been designed by Schiff base dynamic crosslinking. The incorporation of the nanofibers into the hydrogel extremely enhances the stability and mechanical strength of the hydrogel. Taking advantage of the feature, the reinforced hydrogel can restore its original shape while suffering the various external forces on the hydrogel-covered irregular shape wounds. The peptide modified nanofibers reinforced hydrogel (NFRH) not only possesses injectable and self-healing properties, but also inherent antibacterial and hemostatic properties, which can eradicate the bacterial biofilms and induce blood cells and platelets aggregation and finally accelerate the chronic wound healing process. The peptide modified nanofibers reinforced hydrogel has enormous potential to be novel dressing for chronic wounds healing clinically.