Значимость повышения биомаркеров повреждения миокарда (тропонина i, белка, связывающего жирные кислоты) при обострении ХОБЛ

To evaluate the diagnostic and prognostic value of heart injury biomarker (Heart-type fatty acid binding protein, Troponin I) in patients with acute exacerbations of COPD (AECOPD). Prospective observational study. We enrolled 80 hospitalized patients with AECOPD [male 67, female 13, age (64,2±7,8) years, BMI (25,8±8,8) kg/m2]. These patients underwent a complex diagnostic investigation including chest radiography, pulmonary function tests, echocardiography and measurement of serum Tn I (Biomerica), H-FABP (Hycult Biotech) and BNP-fragment (Biomedica). The main causes of AECOPD were purulent bronchitis (43,7%), pneumonia (32,5%), acute decompensation of chronic heart failure (ADCHF) (12,5%) and acute myocardial infarction (AMI) (11,3%). BNP-fragment levels were significantly higher in patients with pneumonia (p=0,007), ADCHF (p=0,002), AMI (p=0,012) than in patients with purulent bronchitis. There were no significant differences between patients with pneumonia and ADCHF (p=0,128), pneumonia and AMI (p=0,651). Patients with AMI had the higher levels of H-FABP than patients with purulent bronchitis (p=0,003), there were no significant differences between other groups of patients. A positive Tn I test was defined as >0,5 ng/mL and its levels were increased in 21,3% of cases, but there were no significant differences between patients' groups. The ROC curve (AUC) for the prediction of hospital mortality of all causes increased for BNP-fragment (AUC presentation: 0,827; 95%CI: 0,729-0,626, pp0,5 ng/mL compared to patients with levels of Tn Ip