Aflatoxin-albumin adducts and correlation with decreased serum levels of vitamins A and E in an adult Ghanaian population.

A study of aflatoxin (AF) exposure and the levels of vitamins A and E was carried out with a group of 507 Ghanaian participants. AFB1–albumin adducts (AFB-AA) were measured by radioimmunoassay and vitamins A and E were measured by high-performance liquid chromatography (HPLC). The average level of serum AFB-AA was 0.94 ± 0.64 (range = 0.1–4.44) pmol mg−1 albumin. Mean levels of vitamins A and E were 1.32 ± 0.48 (range = 0.41–4.85) µmol l−1 and 15.68 ± 4.12 (range = 6.35–30.40) µmol l−1, respectively. A significantly negative correlation was found between serum AFB-AA and vitamin A levels (r = −0.110, p = 0.013). An even stronger, significant negative, correlation was found between serum AFB-AA and vitamin E levels (r = −0.149, p < 0.001). Serum AFB-AA levels were statistically higher (median = 0.985 pmol mg−1 albumin) in subjects who had low levels of both vitamins A and E as compared with the levels (median = 0.741 pmol mg−1 albumin) subjects who had high vitamins A and E levels (p trend = 0.001). To ver...