SOME DATA AVAILABLE FOR THE POTENCY MEASUREMENT OF THE INFLUENZA VACCINE

Neutralization reaction for the potency measurement of the influenza vaccine has so far been carried out by means of mouse inoculation procedure, but this involves some disadvantages, namely first, sometimes non-specific lesions are encountered with in the lungs of mice autopsied and disturbs correct judgement of infective endopoint, second, if newly isolated virus strains would be employed for production and consequently potency measurement of vaccine, it might be difficult to use mice for potency measurement because most of newly isolated strains of influenza virus require more or less time to be adapted to mice, and so on. In these reason experiments were made to obtaine some data necessary for carrying out potency measurement of vaccine with eggs. (Refer to Pp. 123-125)