Efficiency of combined therapy of figuratum and parainfectious erythemas with the use of immunomodulators of different origins and MNRI

The aim of the study was to study the etiopathogenesis of erythema, comparative study of the clinical efficacy of combination therapy with the use of immunomodulators in erythema, the study of the dynamics of immunological parameters as a result of therapy. Materials and methods . The study included 215 adult patients with erythema. Before treatment and 1.5 months after therapy in patients have been studied: the expression of TLRs on MLPC and skin cells by flow cytometry with the use of the mat for TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9 (Caltag Laboratories, USA) using a flow cytometer FC-500 (Beckman Coulter, USA); the subpopulation composition of peripheral blood lymphocytes; the levels of pro-inflammatory and regulatory cytokines in the serum by the method of solid-phase ELISA using test systems company «Biosource» (Austria); the main classes of immunoglobulins (IgG, IgM, IgA) in serum. Results. It was shown that these pathogenetic and diagnostic significance of viruses of the family nerpesviri-dae, bacterial contamination by different types of microorganisms (Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus spp., Proteus vulgaris). A substance containing antigens of conditionally pathogenic microorganisms, and the use of neuro sensorimotor reflex integration (MNRI) contributed to the decline in the number and severity of recurrences of erythema, the extension of the range expressed Toll-like receptors; increase of lymphocytes with immunophenotype CD3+, CD4+, CD25+, CD95+; increase in IFN-y, decreased IL-4; largely reduced the level of total IgE than other types of therapy. Conclusion. The inclusion in therapy of patients with erythema, immunomodulator of bacterial origin and MNRI promotes increase of clinical efficiency and correlates with the correction of immunological disorders.