$^{19}F$ MR Imaging of 5-FU Metabolism in Mice

F imaging of mice was carried out. For F imaging, 5-flouro-uracil (5-FU) was injected into a mouse and in vivo detection of the catabolism of 5-FU to a-fluoro-P-alanine (FBAL) was carried out. The chemical shift selective (CHESS) imaging technique was employed. The 19F spectra and images give temporal and spatial information of the metabolism for 5-FU in mice.