Study on the Correlation of Glutamate and Martix Metalloproteinase-9 with Cerebral Infarctione

Objective: To observe the dynamic changes of glutamate(GLU) and metalloproteinase-9(MMP-9) in patients with cerebral infarction and the relation of Glu、MMP-9 levels to infarction size and intensity of neurological deficit and to investigate clinically the effect of Glu and MMP-9 on the time course in ischemic stroke by detecting Glu and MMP-9 in plasma.Methods: By high-performance liquid chromatography(HLPC),Glu concentration in plasma was determined and by ELISA MMP-9 concentration in plasma was measured in 70 patients with acute cerebral infarction(ACI) and 20 controls on the third day and 14th day after onset.At the same time,Canadian Stroke Scale(CSS) score and cerebral infarction volume(CTV) were also obtained and analyzed.Results: Mean plasma Glu、MMP-9 concentrations in 70 patients significantly elevated compared with controls on the third day,(P0.05).Moreover,Mean plasma Glu、MMP-9 concentrations in patients with CTV≥10 cm3 and CSS 30 were significantly higher than those in the patients with CTV10 cm3 and CSS≤30,(P0.05).On the third day Glu concentrations was significantly positively correlated with MMP-9 in plasma(r=0.499,P0.001).Conclusion: Glu、MMP-9 are involved in the pathologic process of cerebral infarction.The concentrations of Glu and MMP-9 may be taken as an objective guide to judge the degree,size of infarction area and the recent prognosis in acute cerebral infarction.