Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells

Mariano Barbieri,Sheila Q. Xie,Elena Torlai Triglia,Andrea M. Chiariello,Simona Bianco,Ines de Santiago,Miguel R. Branco,David Rueda,Mario Nicodemi,Ana Pombo

Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells

2017

Mariano Barbieri
Sheila Q. Xie
Elena Torlai Triglia
Andrea M. Chiariello
Simona Bianco
Ines de Santiago
Miguel R. Branco
David Rueda
Mario Nicodemi
Ana Pombo

Homotypic interactions between active and Polycomb-repressed promoters co-occurring in the same DNA fiber, rather than CTCF occupancy, explain the 3D HoxB folding pattern.

Keywords:

Induced pluripotent stem cell
Locus (genetics)
Molecular biology
DNA
Genetics
Chromatin
CTCF
Systems biology
Biology
Promoter
Embryonic stem cell
Transcription factor
Gene
Binding site

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