КО-ЭКСПРЕССИЯ РЕЦЕПТОРОВ К ФАКТОРУ НЕКРОЗА ОПУХОЛИ АЛЬФА В СУБПОПУЛЯЦИЯХ Т-КЛЕТОК ПРИ РЕВМАТОИДНОМ АРТРИТЕ

The tumor necrosis factor alpha (TNFα) play key role as the main pro-infl ammatory cytokine in immune processes in rheumatoid arthritis (RA). However, the activity and functions of TNFα can be regulated not only by soluble receptors (which act primarily as neutralizers of action), but also by the amount, density, and co-expression of its membrane-bound receptors type 1 and 2 (TNFR1 and TNFR2). Analysis of the co-expression parameters of TNFR1 and TNFR2 in RA patients compared with healthy donors showed that changes in the amount and co-expression of type 1 and type 2 receptors for TNF-alpha on the surface of immunocompetent cells are associated with indicators of disease activity.