Abstract 20432: Soluble Endoglin is an Independent Predictor of Blood Pressure Response to Hemodynamic Stress in Young Adults

Background: Soluble endoglin (sENG) has been implicated in the abnormal blood pressure response that occurs in mothers who develop preeclampsia on exposure to the hemodynamic stress of pregnancy. Elevated sENG has also been related to resting levels of blood pressure in young adults with a family history of pregnancy complications. Hypothesis: We tested the hypothesis that sENG predicts blood pressure response to the hemodynamic stress of exercise in young adults born following pregnancy complications but that this association also exists more generally in young adults. Methods: We recruited 128 young adults aged 24±4 years (range: 19-38 years) across a range of blood pressures and gestational ages. We completed multimodal assessment, including resting clinic and 24-hour ambulatory blood pressure monitoring, anthropometry, blood sampling, and cardiopulmonary exercise testing, throughout which blood pressures were measured. Enzyme-linked immunosorbent assays (ELISAs) were conducted in duplicate for vascula...