The positive effect of the pH and volume of fluid intake on kidney stones in adult men

The purpose of this study is to investigate the relationship between pH of water or other daily fluid intake and risk of kidney stones in adult men.,This case–control study included 120 adult men with kidney stones and 240 healthy controls matched by age. Participants were selected from the Urmia Imam Khomeini Educational Hospital in the northwest of Iran by the available sampling method between 2017 and 2018. The mean total daily fluid intake of the subjects over the past one year period was collected using a validated 139-item Food Frequency Questionnaire, and the pH of drinking water samples consumed over the past six months was determined using an electrochemical pH meter. Information on physical activity level and socio-demographic characteristics of all participants was collected.,The mean pH of daily water consumption was 7.1 ± 250.3 and 7.4%± 250.3 in case and control groups, respectively. In multivariate logistic regression analysis after adjusting for the covariates 25 a significant relationship was detected between the pH of drinking water (not for other fluid intake26) and kidney stone disease (OR = 0.15, CI 0.06–0.4, P > 1. Moreover, no association was found between the volume of total fluid intake and risk of kidney stones.,These findings support potential protective effects of drinking water intake with higher pH level on preventing kidney stones.