Oxadiazole based Os(IV) compounds as potential DNA intercalator and cytotoxic agents

Abstract Os(IV) compounds and ligands have been synthesized and well characterized. DNA cleavage tendency of compounds has been evaluated using gel electrophoresis and binding behavior has been evaluated by viscosity measurements, absorption titration, fluorescence, and docking studies. All the compounds show the intercalation mode of binding. The binding constant of complexes falls at about 1.8–7.6 × 104 M−1. Bacteriostatic activity of compounds has been evaluated on a series of gram+ve and gram−ve bacteria in terms of their MIC values. Also, the compounds have been screened for in vivo and in vitro cytotoxicity assays on S. Pombe cell’s DNA and HCT-116 cell line. LC50 of ligands and Os(IV) complexes are in the range of 7.92–19.91 and 4.00–11.74 μg/mL respectively.