Advanced MR imaging and 18 F-DOPA PET characteristics of H3K27M-mutant and wild-type pediatric diffuse midline gliomas

Arnoldo Piccardo,Domenico Tortora,Samantha Mascelli,Mariasavina Severino,Gianluca Piatelli,Alessandro Consales,Marco Pescetto,Veronica Biassoni,Elisabetta Schiavello,Michela Massollo,Antonio Verrico,Claudia Milanaccio,Maria Luisa Garrè,Andrea Rossi,Giovanni Morana

Advanced MR imaging and 18 F-DOPA PET characteristics of H3K27M-mutant and wild-type pediatric diffuse midline gliomas

2019

Arnoldo Piccardo
Domenico Tortora
Samantha Mascelli
Mariasavina Severino
Gianluca Piatelli
Alessandro Consales
Marco Pescetto
Veronica Biassoni
Elisabetta Schiavello
Michela Massollo
Antonio Verrico
Claudia Milanaccio
Maria Luisa Garrè
Andrea Rossi
Giovanni Morana

Purpose The aim of this study was to investigate MRI-derived diffusion weighted imaging (DWI), 1H-MR spectroscopy (1H-MRS) and arterial spin labeling (ASL) perfusion imaging in comparison with 18F-dihydroxyphenylalanine (DOPA) PET with respect to diagnostic evaluation of pediatric diffuse midline gliomas (DMG) H3K27M-mutant and wild-type.

Keywords:

Medicine
Pathology
Wild type
Mutant
mr imaging
Diffusion MRI
arterial spin labeling
Perfusion scanning
diagnostic evaluation

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