[COMPARISON OF DYNAMICS OF LEVEL OF PROCALCITONIN, LIPOPOLYSACCHARIDE BINDING PROTEIN AND INTERLEUKIN-6 IN BLOOD SERUM OF EXPERIMENTAL ANIMALS AT STRANGULATED AND OBTURATIVE INTESTINAL OBSTRUCTION].

The aim of research - to study the level of biomarkers of bacterial translocation in the dynamics of the development of two types of intestinal obstruction. In the experiment, 60 white male rats (2 groups with a model of obstructive (OIO) and strangulated (SIO) intestinal obstruction and the Sham control group) determined the level of biomarkers PCT, LBP, IL-6 in blood serum by ELISA. Statistically significant differences in the levels of PCT and LBP were detected in the subgroups of OIO 1 day and SIO 1h/6h, the maximum values were found in the subgroup of OIO 1 day, with SIO the levels of PCT and LBP gradually increased in the post-reperfusion period. The level of IL-6 is statistically significantly increased in the subgroups of OIO 1 day and both SIO. LBP and IL-6 levels are moderately elevated in the Sham group. LBP and PCT are the most valuable markers of bacterial translocation at intestinal obstruction, while LBP is an effective marker IL-6 the degree of systemic inflammatory response.