Anti-proliferation Effects of Isorhamnetin Isolated from Persicaria thunbergii on Cancer Cell Lines

Isorhamnetin from the aerial parts of Persicaria thunbergii has been reported to have anti-tumor activity mediated by the inhibition of farnesyl protein transferase. In this study, we investigated the antiproliferation effects of isorhamnetin on NIH3T3, K-RAS, H-RAS and SW620 cells, and it showed antiproliferative effects in a dose-dependent manner with IC50 value 4.1, 7.9, 20.2, and 22.4 ug/ml, repectively.