The effect of hyaluronic acid carboxymethyl cellulose on the healing of colonic anastomosis in rats.

This study demonstrates the effect of hyaluronic acid-carboxymethylcellulose on the healing of colonic anastomosis.30 female Wistar-Albino rats were divided into three groups; control group 1 (n=10), treated with hyaluronic acid-carboxymethylcellulose, group 2 (n=8) treated with HBO and group 3 with hyaluronic acid-carboxymethylcellulose and HBO.Bursting pressure and rupture strength were significantly higher in the group 3 compared to other two groups (p 0.05). But the evaluation of inflammation showed a statistical significance (p<0.001) such as as granulation (p<0.05).This study did not detect the negative affect of seprafilm on wound healing. Combined treatment with seprafilm and HBO has a favorable therapeutic effect on the healing of ischemic colonic anastomosis (Tab. 4, Fig. 3, Ref. 15). Full Text (Free, PDF) www.bmj.sk.