Pharmacodynamic analysis of tumour perfusion assessed by 15O-water-PET imaging during treatment with sunitinib malate in patients with advanced malignancies

Andrew M. Scott,Paul Mitchell,Graeme O’Keefe,Timothy Saunder,Rodney J. Hicks,Aurora Poon,Charles M. Baum,Nicoletta Brega,Timothy J. McCarthy,Guy C. Toner

Pharmacodynamic analysis of tumour perfusion assessed by 15O-water-PET imaging during treatment with sunitinib malate in patients with advanced malignancies

2012

Andrew M. Scott
Paul Mitchell
Graeme O’Keefe
Timothy Saunder
Rodney J. Hicks
Aurora Poon
Charles M. Baum
Nicoletta Brega
Timothy J. McCarthy
Guy C. Toner

Background We evaluated pharmacodynamic changes in tumour perfusion using positron emission tomography (PET) imaging with 15O-water to assess biological response to sunitinib, a multitargeted tyrosine kinase inhibitor.

Keywords:

Positron emission tomography
Pharmacodynamics
Sunitinib malate
Nuclear medicine
Tyrosine-kinase inhibitor
Medicine
Perfusion
Sunitinib
Internal medicine
Oncology
Breast cancer
Cardiac imaging
In vivo

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