Reinvestigation of the tautomerism of some substituted 2-hydroxypyridines
2002
The tautomerism of some substituted 2-hydroxypyridines is investigated by UV/Vis- and 1 H-, and 13 C- NMR spectroscopic methods, with the aid of the N-Me and O-Me fixed parents. NMR spectroscopic data do not allow discrimination between the two tautomeric forms (with the exception of the unsubstituted 2-hydroxypyridine), while UV/Vis- data permit the quantitative determination, in different solvents, of the amounts of the two forms. The electronic substituent effect and the change of solvent are discussed. An X-Ray diffraction study carried out on a crystal of 2-hydroxy-5-nitropyridine (7) reveals that this compound, in the solid state, is in the oxo-form.
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