Analgesic effect of breast feeding in term neonates: randomised controlled trial

Abstract Objectives: To investigate whether breast feeding is effective for pain relief during venepuncture in term neonates and compare any effect with that of oral glucose combined with a pacifier. Design: Randomised controlled trial. Participants: 180 term newborn infants undergoing venepuncture; 45 in each group. Interventions: During venepuncture infants were either breast fed (group 1), held in their mother9s arms without breast feeding (group 2), given 1 ml of sterile water as placebo (group 3), or given 1 ml of 30% glucose followed by pacifier (group 4). Video recordings of the procedure were assessed by two observers blinded to the purpose of the study. Main outcome measures: Pain related behaviours evaluated with two acute pain rating scales: the Douleur Aigue Nouveau-ne scale (range 0 to 10) and the premature infant pain profile scale (range 0 to 18). Results: Median pain scores (interquartile range) for breast feeding, held in mother9s arms, placebo, and 30% glucose plus pacifier groups were 1 (0–3), 10 (8.5-10), 10 (7.5-10), and 3 (0–5) with the Douleur Aigue Nouveau-ne scale and 4.5 (2.25-8), 13 (10.5-15), 12 (9–13), and 4 (1–6) with the premature infant pain profile scale. Analysis of variance showed significantly different median pain scores (P Conclusions: Breast feeding effectively reduces response to pain during minor invasive procedure in term neonates. What is already known on this topic Current pharmacological treatments are not appropriate for pain relief during minor procedures like venepuncture or heel prick in newborn infants Oral sweet solutions, non-nutritive sucking, and skin to skin contact reduce procedural pain in newborn infants What this study adds Breast feeding during a painful procedure effectively reduces the response to pain in newborn infants The analgesic properties of breast feeding are at least as potent as the combination of sweet solutions and a pacifier