Clopidogrel and the possibility of drug-drug interaction in primary health care.

Introduction Clopidogrel ineffectiveness is a serious problem in antiplatelet therapy. Many factors may contribute to this phenomenon. One of them is clopidogrel drug–drug interaction with CYP2C19 and CYP3A4 enzyme inhibitors. The main goal of this descriptive study was to assess the prevalence of cases of clopidogrel–drug interactions in the primary health care physicians' practices.