Effects of Th22 cells and IL-22 in tumors

Th22 cells,a new subset of CD4 + T-helper cells,and is characterized by secreting interleukin (IL)-22 but not IL-17 or interferon (IFN)-γ.Research shows that Th22 cells participate in the immunologic processes of autoimmune diseases and infectious diseases.Recent studies confirm that Th22 cells and related cytokines distribute and express in a verity of tumor tissues,but the conclusions of their repressive or stimulative functions in tumorigenesis are different.The studies on Th22 cell expression in tumors and its underlying mechanism can provide a theoretical basis for specific targeted tumor therapy. Key words: Neoplasms;  T helper 22 ;  Interleukin-22